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Researchers identify CD8 T cells as contributors to Krabbe disease pathology; repurposed immunotherapies show promise in models
Summary
A neuroscience researcher reported lab findings that CD8 T cells contribute to Krabbe disease pathology in animal models and that existing immunomodulatory therapies that block T-cell trafficking improved survival and neuropathology in mice.
A University researcher told the RDAC that new preclinical work implicates cytotoxic CD8 T cells in the neuropathology of Krabbe disease and that therapies which block T-cell trafficking produced marked benefit in animal models.
The nut graf: Steven Crocker said his lab found abundant CD8 T cells in affected white-matter areas in mouse, dog and human tissue and that depleting or blocking these cells…
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