Governor Ron DeSantis used the Mayo Clinic event to place the new particle therapy facility in the context of state cancer initiatives and personal experience, and to reiterate other policy positions including immigration enforcement.

DeSantis said Florida has increased cancer funding and programs, calling out the Cancer Connect Collaborative, the Innovation Fund and the Casey DeSantis research program. He stated that "in my tenure as governor" the state has put more than $1,000,000,000 into cancer research and that the 2025 cancer budget is "$218,000,000." He credited First Lady Casey DeSantis with advancing the state's cancer efforts.

First Lady Casey DeSantis spoke about her own illness and advocacy, saying, "I would never say it was a good thing that I got sick, but I will say I am just so humbled to have had a very, very small part in seeing something so historic happen." She referenced pediatric funding and the Casey DeSantis research program.

At one point, a speaker cited the state Innovation Fund to illustrate the range of projects the state will test and said, "Ivermectin, we've incentivized that through the Department of Health with this innovation fund because it's in generic form." That statement was presented as an example of the state's willingness to fund exploratory approaches; no clinical results were offered during the event.

DeSantis also spoke at length about immigration enforcement and cooperation with federal agencies, saying the state has provided detention and staging capacity and that additional state facilities would not be opened without federal approval and reimbursement. He told attendees that the state has logistical capabilities and would work with the Department of Homeland Security where authorized.

The remarks mixed policy advocacy, personal testimony and programmatic claims; the event did not include independent documentation or a legislative vote to corroborate the funding totals or the list of funded projects. Officials closed by celebrating the facility and a ceremonial activation of the beamline.