PROSE: Protein Sequencing

Defense Advanced Research Projects Agency (DARPA) · February 19, 2026

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Proteins versus DNA

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Unidentified Speaker (Presenter) opened by distinguishing DNA sequencing from protein analysis, saying proteins are where biology "actually does the work" and are how organisms sense, compute and respond to the world.

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Unidentified presenter described limitations of current protein characterization tools and announced DARPA's new PROS program, which aims to develop microsystems to directly read the chemical diversity of proteins and enable applications in health care, biomanufacturing, agriculture and national security.

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