Mississippi County
countyMississippi County is located in the southeastern "Bootheel" region of Missouri, with the Mississippi River forming its eastern border. Charleston is the county seat and largest city. As of 2024, the population was estimated to be around 11,750. The county's history is tied to its fertile land and proximity to the river, shaping its agricultural economy and rural character. Agriculture is a key component of Mississippi County's economy, with crops like soybeans, corn, and cotton being significant. The county's rich soil, a result of its location in a floodplain, supports this agricultural activity. However, the area faces economic challenges, including a relatively lower median household income compared to the national average. Mississippi County offers a glimpse into the history of the region, with sites like the Towosahgy State Historic Site preserving the remains of an ancient Native American community. The county's location along the Mississippi River also played a role in the Civil War, with the Battle of Belmont being a notable event. Today, the county maintains its rural charm and agricultural heritage.
Mississippi County, Missouri
- Classification
- County
- FIPS Code
- 29133
- Country
- United States
- County
- Mississippi County
- Region
- Bootheel
- Total Area
- 429 sq mi
- Land Area
- 412 sq mi
- Water Area
- 17 sq mi
- Latitude
- 36.83
- Longitude
- -89.29
- Climate
- Southeastern Missouri climate
- Notable Features
- Mississippi River · Tywappity Bottoms floodplain
- Neighboring Areas
- Scott County, MO · New Madrid County, MO · Alexander County, IL · Ballard County, KY · Carlisle County, KY · Fulton County, KY · Hickman County, KY
- Population (2020)
- 12,577
- Est. Population (2024)
- 11,750
- Median Age
- 42.2
- Median Income
- $46,258
- Poverty Rate
- 18.9%
- Owner-Occupied
- 60.9%
- Racial & Ethnic Composition
- 70.7% White, 22.7% Black or African American, 4.7% Two or More Races
- Government Type
- County Commission
- Governing Body
- County Commission
- Body Size
- 3 members










- Unemployment Rate
- 5.1%
- Economic Profile
- Agriculture-based · Rural
- Employment Sectors
- Health Care & Social Assistance · Retail Trade · Manufacturing
- Schools
- 3
- Students
- 776
- School Districts
- Charleston R-I School District · East Prairie R-II School District · Scott County R-IV School District
- Transportation
- Major highways · Proximity to Mississippi River
- Major Facilities
- Courthouse
- Outdoor Access
- Yes
- Major Recreation Areas
- Big Oak Tree State Park · Towosahgy State Historic Site
- Founded
- 1845
- Named After
- Mississippi River
- Historical Significance
- Part of the 'Tywappity Bottoms'; Early settlement by American pioneers; Civil War battle site
- Key Events
- Battle of Belmont · Civil War skirmishes
